Have you tasted a clove? Well, that’s a stupid question! We all have tasted a clove at some point of our life. So, have you noticed the spiciness present in a clove? That’s a partial product of Caryophyllene, a natural sesquiterpene present in many natural plants in addition to clove. Caryophyllene is a chemical compound present in several essential oils such as black caraway, black pepper, cinnamon, lavender, rosemary, copaiba, hemp, etc. Yes, even hemp, which means if you are consuming full-spectrum hemp CBD sublingual drops, you are adding Caryophyllene to your body. Caryophyllene is an FDA approved food additive and has substantial health benefits which you might experience on adding Caryophyllene rich food in your diet. Here is how this natural terpene can assist you in maintaining your health! Quick Benefits Of Caryophyllene Caryophyllene targets the genes SIRT1, CREB, PGC-1a, and PPAR-gamma which are responsible for mitochondrial functions which, in turn, contributes in increasing the lifespan. Caryophyllene binds with CB2 receptors and stimulate the pathway Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) which elevates the glutathione levels protecting the brain against glutamate-induced oxidative stress. In all, this terpene decreases the neuroinflammation through its antioxidant properties. Like we said, Caryophyllene activates the CB2 receptors and decreases neuroinflammation. But that’s not all. It regulates PPAR-gamma and reduces amyloid-beta plaques which are responsible for neurodegeneration. But the cherry on the top would be Caryophyllene’s capacity to increase Brain-Derived Neurotrophic Factor levels, and this induces neurogenesis. Caryophyllene is a perfect antimicrobial agent with a capacity to fight an array of bacteria, fungi, parasites, and virus. In fact, cloves are included in most Ayurvedic formulations. This terpene may also prove to be a shield for tick bites and mosquito induced illnesses such as dengue fever, yellow fever, and chikungunya. As Caryophyllene activates the CB2 receptors, it’s specific that it works closely with the endocannabinoid system. It can elevate the flow of endorphins and reduce the inflammation blocking the pain. Caryophyllene also has potential analgesic effects and synergistic effects with DHA, both of which contributes in its pain-reducing properties. Caryophyllene was reported to have inhibited the tumor growth in mice which has led the researchers to believe that it has anti-cancer properties. It has also been observed that the effects of Caryophyllene can be stronger if it’s oxidized. Caryophyllene activates the ACC1, AMPK, CB2, and PPAR-gamma which contributes in keeping the health of a liver intact. It prevents liver scarring, liver inflammation, high levels of triglycerides, and also non-alcoholic fatty liver diseases. Caryophyllene reduces the effect of pro-inflammatory cytokines such as TH1 and TH17 which makes it a good agent for Multiple Sclerosis. It slows the progression of MS and can help the patients with its pain. Being a natural component, there’s definitely no harm in consuming Caryophyllene in logical quantities. Many CBD manufactures have made sure to proffer entourage oils which encompass such crucial terpenes. I have been ordering CBD products online since its inception in the industry and have found it to be quite useful, especially the CBD coffee beans I am now routined to.